Design, synthesis, and anti-influenza viral activities of 1,3-diarylprop-2-en-1-ones: a novel class of neuraminidase inhibitors
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- Title
- Design, synthesis, and anti-influenza viral activities of 1,3-diarylprop-2-en-1-ones: a novel class of neuraminidase inhibitors
- Author(s)
- M Kinger; Y D Park; J H Park; M G Hur; Hyung Jae Jung; Su-Jin Park; Woo Song Lee; S W Kim; S D Yang
- Bibliographic Citation
- Archives of Pharmacal Research, vol. 35, no. 4, pp. 633-638
- Publication Year
- 2012
- Abstract
- A series of 1,3-diarylprop-2-en-1-one derivatives 3a-v have been synthesized and evaluated for their ability to inhibit neuraminidase (NA). Among the prepared compounds, the less lipophilic derivative 3k showed the most potent in vitro inhibitory activity against NA with an IC50 value of 1.5 μM.
- ISSN
- 0253-6269
- Publisher
- Pharmaceutical Soc Korea
- Full Text Link
- http://dx.doi.org/10.1007/s12272-012-0406-2
- Type
- Article
- Appears in Collections:
- Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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