Design, synthesis, and anti-influenza viral activities of 1,3-diarylprop-2-en-1-ones: a novel class of neuraminidase inhibitors

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Title
Design, synthesis, and anti-influenza viral activities of 1,3-diarylprop-2-en-1-ones: a novel class of neuraminidase inhibitors
Author(s)
M Kinger; Y D Park; J H Park; M G Hur; Hyung Jae JungSu-Jin ParkWoo Song Lee; S W Kim; S D Yang
Bibliographic Citation
Archives of Pharmacal Research, vol. 35, no. 4, pp. 633-638
Publication Year
2012
Abstract
A series of 1,3-diarylprop-2-en-1-one derivatives 3a-v have been synthesized and evaluated for their ability to inhibit neuraminidase (NA). Among the prepared compounds, the less lipophilic derivative 3k showed the most potent in vitro inhibitory activity against NA with an IC50 value of 1.5 μM.
Keyword
1,3-Diarylprop-2-en-1-onesAnti-influenza activityNeuraminidaseSynthesis
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-012-0406-2
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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