Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) transactivation

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Title
Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) transactivation
Author(s)
Y D Kim; T Li; S W Ahn; D K Kim; J M Lee; S L Hwang; Yong Hoon KimChul Ho Lee; I K Lee; J Y L Ciang; H S Choi
Bibliographic Citation
Journal of Biological Chemistry, vol. 287, no. 44, pp. 37098-37108
Publication Year
2012
Abstract
Background: Growth hormone (GH) is involved in hepatic glucose metabolism. Results: GH increased hepatic gluconeogenesis through STAT5 transactivation, which was abolished by the metformin-ATMAMPK-SHP pathway. Conclusion: The metformin-ATM-AMPK-SHP network prevents the increase of hepatic gluconeogenesis by the GH-dependent pathway. Significance: The ATM-AMPK-SHP pathway may provide a novel mechanism for regulating hepatic glucose homeostasis via a GH-dependent pathway.
ISSN
0021-9258
Publisher
Amer Soc Biochemistry Molecular Biology Inc
DOI
http://dx.doi.org/10.1074/jbc.M112.339887
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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