Overexpression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in colorectal cancer

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Title
Overexpression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in colorectal cancer
Author(s)
K S Kim; Jong-Tae KimSeon-Jin Lee; M A Kang; I S Choe; Yun Hee Kang; Seon-Young KimYoung Il Yeom; Y H Lee; J H Kim; K H Kim; C N Kim; J W Kim; M S Nam; Hee Gu Lee
Bibliographic Citation
Clinica Chimica Acta, vol. 415, no. 1, pp. 12-19
Publication Year
2013
Abstract
Background: Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) inhibits anoikis and affects the malignant phenotype of cancer cells. In this study, we analyzed CEACAM6 as a gene that is highly upregulated in colon cancer tissues, and examined the assertion that CEACAM6 might be a suitable candidate tumor marker for the diagnosis of colon cancer. Methods: CEACAM6 gene expression in human colon tissues was performed by tissue microarray and analyzed using RT-PCR (each of normal and tumor tissue, n=. 40) and immunohistochemical and clinicopathological (colon cancer patients, n=. 143) analyses. Results: CEACAM6 transcriptional and translational levels were significantly upregulated in human tumor tissues compared to non-tumor regions, and clinicopathological analysis revealed a significant correlation between CEACAM6 protein expression and Dukes' stage (. p<. 0.001). High expression levels of CEACAM6 were significantly associated with lower overall survival (. p<. 0.001) and shorter recurrence-free survival (. p<. 0.001). We demonstrated that knockdown of CEACAM6 with CEACAM6-specific small interfering RNA in colorectal cancer cells attenuated invasivity (35%); conversely, the overexpression of CEACAM6 increased invasiveness. Conclusions: CEACAM6 is significantly upregulated in colon cancer tissues and is closely associated with poor prognosis, indicating that CEACAM6 might be used as a tumor biomarker and a potential therapeutic target for colon cancer.
Keyword
Carcinoembryonic antigen-related cell adhesion molecule 6Colon cancerInvasivenessMicroarrayPrognosis
ISSN
0009-8981
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.cca.2012.09.003
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Korea Bioinformation Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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