Anti-human rhinoviral activity of polybromocatechol compounds isolated from the rhodophyta, Neorhodomela aculeate

Cited 16 time in scopus
Metadata Downloads
Title
Anti-human rhinoviral activity of polybromocatechol compounds isolated from the rhodophyta, Neorhodomela aculeate
Author(s)
S H Park; J H Song; T Kim; W S Shin; G M Park; S Lee; Y J Kim; P Choi; H Kim; Hui Seong Kim; Dur Han Kwon; H J Choi; J Ham
Bibliographic Citation
Marine Drugs, vol. 10, no. 10, pp. 2222-2233
Publication Year
2012
Abstract
An extract of the red alga, Neorhodomela aculeata, exhibited antiviral activity against human rhinoviruses. Bioassay-guided purification was performed to yield six compounds, which were subsequently identified as lanosol (1) and five polybromocatechols (2-6) by spectroscopic methods, including 1D and 2D NMR and mass spectrometric analyses. Structurally, all of these compounds, except compound 5, contain one or two 2,3-dibromo-4,5-dihydroxyphenyl moieties. In a biological activity assay, compound 1 was found to possess antiviral activity with a 50% inhibitory concentration (IC 50) of 2.50 μg/mL against HRV2. Compound 3 showed anti-HRV2 activity, with an IC 50 of 7.11 μg/mL, and anti-HRV3 activity, with an IC 50 of 4.69 μg/mL, without demonstrable cytotoxicity at a concentration of 20 μg/mL. Collectively, the results suggest that compounds 1 and 3 are candidates for novel therapeutics against two different groups of human rhinovirus.
Keyword
Antiviral activityHuman rhinovirusNeorhodomela aculeatePolybromocatechol compoundsRed alga
ISSN
1660-3397
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/md10102222
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.