A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells

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Title
A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells
Author(s)
Jung Woon Lee; Y Xia; Mi Young Son; G Jin; Binna Seol; Min-Jeong Kim; Myung Jin Son; M Do; M Lee; D Kim; K Lee; Yee Sook Cho
Bibliographic Citation
Angewandte Chemie-International Edition, vol. 51, no. 50, pp. 12509-12513
Publication Year
2012
Abstract
Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).
Keyword
pluripotencyreprogrammingsmall moleculesstem cellsgene expression
ISSN
1433-7851
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/anie.201206691
Type
Article
Appears in Collections:
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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