Open Access@KRIBBDivision of Research on National ChallengesEnvironmental diseases research center1. Journal Articles
A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells
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- Title
- A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells
- Author(s)
- Jung Woon Lee; Y Xia; Mi Young Son; G Jin; Binna Seol; Min-Jeong Kim; Myung Jin Son; M Do; M Lee; D Kim; K Lee; Yee Sook Cho
- Bibliographic Citation
- Angewandte Chemie-International Edition, vol. 51, no. 50, pp. 12509-12513
- Publication Year
- 2012
- Abstract
- Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).
- ISSN
- 1433-7851
- Publisher
- Wiley
- Full Text Link
- http://dx.doi.org/10.1002/anie.201206691
- Type
- Article
- Appears in Collections:
- Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
Division of A.I. & Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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