Ganglioside GM1 influences the proliferation rate of mouse induced pluripotent stem cells

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Title
Ganglioside GM1 influences the proliferation rate of mouse induced pluripotent stem cells
Author(s)
J S Ryu; Kyu Tae Chang; J T Lee; M U Lim; H K Min; Y J Na; S B Lee; G Moussavou; Sun-Uk KimJi Su Kim; K Ko; K Ko; K A Hwang; E J Jeong; Jeong Woong Lee; Y K Choo
Bibliographic Citation
BMB Reports, vol. 45, no. 12, pp. 713-718
Publication Year
2012
Abstract
Gangliosides play important roles in the control of several biological processes, including proliferation and transmembrane signaling. In this study, we demonstrate the effect of ganglioside GM1 on the proliferation of mouse induced pluripotent stem cells (miPSCs). The proliferation rate of miPSCs was lower than in mouse embryonic stem cells (mESCs).Fluorescence activated cell sorting analysis showed that the percentage of cells in the G2/M phase in miPSCs was lower than that in mESCs. GM1 was expressed in mESCs, but not miPSCs. To confirm the role of GM1 in miPSC proliferation, miPSCs were treated with GM1. GM1-treated miPSCs exhibited increased cell proliferation and a larger number of cells in the G2/M phase. Furthermore, phosphorylation of mitogen-activated protein kinases was increased in GM1- treated miPSCs.
Keyword
Cell cycleGanglioside GM1MAP kinaseMouse induced pluripotent stem cells (miPSCs)Proliferation
ISSN
1225-8687
Publisher
South Korea
DOI
http://dx.doi.org/10.5483/BMBRep.2012.45.12.138
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Primate Resources Center > 1. Journal Articles
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
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