Ganglioside GM1 influences the proliferation rate of mouse induced pluripotent stem cells

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dc.contributor.authorJ S Ryu-
dc.contributor.authorKyu Tae Chang-
dc.contributor.authorJ T Lee-
dc.contributor.authorM U Lim-
dc.contributor.authorH K Min-
dc.contributor.authorY J Na-
dc.contributor.authorS B Lee-
dc.contributor.authorG Moussavou-
dc.contributor.authorSun-Uk Kim-
dc.contributor.authorJi Su Kim-
dc.contributor.authorK Ko-
dc.contributor.authorK Ko-
dc.contributor.authorK A Hwang-
dc.contributor.authorE J Jeong-
dc.contributor.authorJeong Woong Lee-
dc.contributor.authorY K Choo-
dc.date.accessioned2017-04-19T09:36:12Z-
dc.date.available2017-04-19T09:36:12Z-
dc.date.issued2012-
dc.identifier.issn12258687-
dc.identifier.uri10.5483/BMBRep.2012.45.12.138ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11130-
dc.description.abstractGangliosides play important roles in the control of several biological processes, including proliferation and transmembrane signaling. In this study, we demonstrate the effect of ganglioside GM1 on the proliferation of mouse induced pluripotent stem cells (miPSCs). The proliferation rate of miPSCs was lower than in mouse embryonic stem cells (mESCs).Fluorescence activated cell sorting analysis showed that the percentage of cells in the G2/M phase in miPSCs was lower than that in mESCs. GM1 was expressed in mESCs, but not miPSCs. To confirm the role of GM1 in miPSC proliferation, miPSCs were treated with GM1. GM1-treated miPSCs exhibited increased cell proliferation and a larger number of cells in the G2/M phase. Furthermore, phosphorylation of mitogen-activated protein kinases was increased in GM1- treated miPSCs.-
dc.publisherSouth Korea-
dc.titleGanglioside GM1 influences the proliferation rate of mouse induced pluripotent stem cells-
dc.title.alternativeGanglioside GM1 influences the proliferation rate of mouse induced pluripotent stem cells-
dc.typeArticle-
dc.citation.titleBMB Reports-
dc.citation.number12-
dc.citation.endPage718-
dc.citation.startPage713-
dc.citation.volume45-
dc.contributor.affiliatedAuthorSun-Uk Kim-
dc.contributor.affiliatedAuthorJi Su Kim-
dc.contributor.affiliatedAuthorJeong Woong Lee-
dc.contributor.alternativeName류재성-
dc.contributor.alternativeName장규태-
dc.contributor.alternativeName이주택-
dc.contributor.alternativeName임맑음-
dc.contributor.alternativeName민현기-
dc.contributor.alternativeName나윤주-
dc.contributor.alternativeName이수빈-
dc.contributor.alternativeNameMoussavou-
dc.contributor.alternativeName김선욱-
dc.contributor.alternativeName김지수-
dc.contributor.alternativeName고기남-
dc.contributor.alternativeName고기성-
dc.contributor.alternativeName황경아-
dc.contributor.alternativeName정은정-
dc.contributor.alternativeName이정웅-
dc.contributor.alternativeName추영국-
dc.identifier.bibliographicCitationBMB Reports, vol. 45, no. 12, pp. 713-718-
dc.identifier.doi10.5483/BMBRep.2012.45.12.138-
dc.subject.keywordCell cycle-
dc.subject.keywordGanglioside GM1-
dc.subject.keywordMAP kinase-
dc.subject.keywordMouse induced pluripotent stem cells (miPSCs)-
dc.subject.keywordProliferation-
dc.subject.localCell cycle-
dc.subject.localGanglioside GM1-
dc.subject.localMAP kinase-
dc.subject.localMouse induced pluripotent stem cells (miPSCs)-
dc.subject.localProliferation-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Primate Resources Center > 1. Journal Articles
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
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