Colorimetric detection of UV light-induced single-strand DNA breaks using gold nanoparticles

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Title
Colorimetric detection of UV light-induced single-strand DNA breaks using gold nanoparticles
Author(s)
Joong Hyun Kim; Chan Ho Chung; Bong Hyun Chung
Bibliographic Citation
Analyst, vol. 138, no. 3, pp. 783-786
Publication Year
2013
Abstract
We developed a colorimetric method to specifically detect single-strand DNA breaks using gold nanoparticles. In our assay, broken DNA cannot stabilize gold nanoparticles to prevent salt-induced aggregation as good as intact DNA can, and this effect can be easily observed with the naked eye as a red-to-purple color change.
ISSN
0003-2654
Publisher
Royal Soc Chem
DOI
http://dx.doi.org/10.1039/c2an36458a
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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