Dimerization of pro-oncogenic protein Anterior Gradient 2 is required for the interaction with BiP/GRP78

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Title
Dimerization of pro-oncogenic protein Anterior Gradient 2 is required for the interaction with BiP/GRP78
Author(s)
Joohyun Ryu; Sung Goo Park; Phil Young Lee; S Cho; D H Lee; G H Kim; Jeong Hoon KimByoung Chul Park
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 430, no. 2, pp. 610-615
Publication Year
2013
Abstract
Anterior Gradient 2 (AGR2), an ER stress-inducible protein, has been reported to be localized in endoplasmic reticulum (ER) and its level is elevated in numerous metastatic cancers. Recently, it has been demonstrated that AGR2 is involved in the control of ER homeostasis. However, the molecular mechanism how AGR2 regulates ER stress response remains unclear. Herein we show that AGR2 homo-dimerizes through an intermolecular disulfide bond. Moreover, dimerization of AGR2 attenuates ER stress-induced cell death through the association with BiP/GRP78. Thus, these results suggest that dimerization of AGR2 is crucial in mediating the ER stress signaling pathway.
Keyword
AGR2DimerizationER stressUPR signaling pathway
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2012.11.105
Type
Article
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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