Bifunctional nanoparticles constructed using one-pot encapsulation of a fluorescent polymer and magnetic (Fe3O4) nanoparticles in a silica shell

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Title
Bifunctional nanoparticles constructed using one-pot encapsulation of a fluorescent polymer and magnetic (Fe3O4) nanoparticles in a silica shell
Author(s)
Chang-Soo Lee; H H Chang; Pan Kee Bae; Juyeon Jung; Bong Hyun Chung
Bibliographic Citation
Macromolecular Bioscience, vol. 13, no. 3, pp. 321-331
Publication Year
2013
Abstract
Integration of biocompatible silica with a fluorescent polymer (PDDF) and superparamagnetic iron oxide nanoparticles (Fe3O4) to form uniform core-shell nanostructures has the great potential to form particles for use in multimodal bioimaging applications. Core-shell nanoparticles (PDDF/Fe3O4@SiO2) exhibit fluorescent and magnetic properties that are favorable for their use in magnetic separation and guiding applications, as well as optical and magnetic resonance (MR) imaging capabilities. With the biological analysis in an in vitro intracellular permeation and cytotoxicity test, chemical conjugation of the surface using folic acid (FA) molecules can provide the nanoparticles with cell-targeting properties, localizing the nanoparticles to folate receptors (FRs) on target KB cells that over-express the FRs.
Keyword
BioimagingFluorescent polymersMultifunctional materialsTumor targeting
ISSN
1616-5187
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/mabi.201200308
Type
Article
Appears in Collections:
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
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