Differential anti-inflammatory and analgesic effects by enantiomers of zaltoprofen in rodents

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Title
Differential anti-inflammatory and analgesic effects by enantiomers of zaltoprofen in rodents
Author(s)
Ik Jun Jo; Chang Woo LeeMyeong Youl Lee; Moo Rim Kang; Ji Eun Yun; Soo Jin Oh; S B Han; K Lee; S K Park; H M Kim; S H Jung; Jong Soon Kang
Bibliographic Citation
International Immunopharmacology, vol. 16, no. 4, pp. 457-460
Publication Year
2013
Abstract
In the present study, we investigated the effect of zaltoprofen enantiomers on inflammation and pain and compared their effect with racemic zaltoprofen. S(+)-zaltoprofen potently inhibited the inflammatory response in carrageenan-induced paw edema model, whereas R(-)-zaltoprofen did not. Moreover, the anti-inflammatory effect of S(+)-zaltoprofen was stronger than that of racemic zaltoprofen, suggesting that S(+)-zaltoprofen is an active component of racemic zaltoprofen in terms of anti-inflammatory activity. In contrast, the results of acetic acid-induced writhing model demonstrated that no significant analgesic effect was observed by racemic zaltoprofen and zaltoprofen enantiomers at doses used in carrageenan-induced paw edema model. However, racemic zaltoprofen and zaltoprofen enantiomers all exerted an analgesic effect at higher doses, which is inconsistent with the result of carrageenan-induced paw edema model. Gastric ulcers induced by racemic zaltoprofen and zaltoprofen enantiomers were minimal. Taken together, these results suggest that S(+)-zaltoprofen is a potent and active anti-inflammatory component of racemic zaltoprofen, but both S(+)-zaltoprofen and R(-)-zaltoprofen might seem to contribute to the analgesic effect of racemic zaltoprofen.
Keyword
AnalgesicAnti-inflammatoryEnantiomerZaltoprofen
ISSN
1567-5769
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.intimp.2013.05.008
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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