Bimodal perfluorocarbon nanoemulsions for nasopharyngeal carcinoma targeting

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Bimodal perfluorocarbon nanoemulsions for nasopharyngeal carcinoma targeting
Pan Kee Bae; Juyeon Jung; S J Lim; D Kim; S K Kim; Bong Hyun Chung
Bibliographic Citation
Molecular Imaging and Biology, vol. 15, no. 4, pp. 401-410
Publication Year
Purpose: The aim of this study was to perform the detection of folate receptor (FR)-positive tumors with a bimodal imaging contrast agent, a perfluorocarbon (PFC)/rhodamine nanoemulsion, providing both 19F-based magnetic resonance imaging (MRI) and fluorescence imaging capabilities. Procedures: The PFC/rhodamine nanoemulsion was further infused with phospholipid-anchored folate to improve the ability to target FR-expressing tumors. The preferential accumulation of the FR-targeted bimodal nanoemulsion in FR-positive tumor sites was monitored by both 19F-MRI and optical imaging. Results: The FR-targeted PFC nanoemulsion had no significant effect on cell viability, and the size and fluorescence signal of PFC nanoemulsion were very stable. These nanoprobes were successfully delivered into FR-positive tumor xenograft models and showed significantly enhanced signal intensities of 19F-MRI and fluorescence imaging in the tumor area. Conclusions: The folate-PFC/rhodamine nanoemulsion has a great potential to serve as a useful optical and 19F-MRI agent for the diagnosis and targeting of FR-positive tumor.
19F-MRBimodal nanoemulsionCancerCancer-specific imagingMRIOptical imagingPerfluorocarbon
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Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
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