Candidate target genes for the Saccharomyces cerevisiae transcription factor, Yap2

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Title
Candidate target genes for the Saccharomyces cerevisiae transcription factor, Yap2
Author(s)
Seo Young Bang; Jeong Hoon Kim; Phil Young Lee; Seung-Wook Chi; S Cho; G S Yi; P K Myung; Byoung Chul ParkKwang-Hee BaeSung Goo Park
Bibliographic Citation
Folia Microbiologica, vol. 58, no. 5, pp. 403-408
Publication Year
2013
Abstract
In Saccharomyces cerevisiae, the Yap family of basic leucine zipper (bZip) proteins contains eight members. The Yap family proteins are implicated in a variety of stress responses; among these proteins, Yap1 acts as a major regulator of oxidative stress responses. However, the functional roles of the remaining Yap family members are poorly understood. To elucidate the function of Yap2, we mined candidate target genes of Yap2 by proteomic analysis. Among the identified genes, FRM2 was previously identified as a target gene of Yap2, which confirmed the validity of our screening method. YNL134C and YDL124W were also identified as candidate Yap2 target genes. These genes were upregulated in strains overexpressing Yap2 and possess Yap2 target sequences in their promoter regions. Furthermore, chromatin immunoprecipitation assays showed that YNL134C and YDL124W have Yap2 binding motif. These data will help to elucidate the functional role of Yap2.
ISSN
0015-5632
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s12223-013-0224-z
Type
Article
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
Division of Biomedical Research > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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