Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors

Cited 36 time in scopus
Metadata Downloads
Title
Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors
Author(s)
Sunghyun Kang; Hye-Jin Min; M S Kang; M G Jung; Semi Kim
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 23, no. 6, pp. 1748-1751
Publication Year
2013
Abstract
TMPRSS4 is a novel type II transmembrane serine protease that has been implicated in the invasion and metastasis of colon cancer cells. In this study, a novel series of 2-hydroxydiarylamide derivatives were synthesized and evaluated for inhibiting TMPRSS4 serine protease activity and suppressing cancer cell invasion. These derivatives demonstrated good inhibitory activity against TMPRSS4 serine protease, which correlated with the promising anti-invasive activity of colon cancer cells overexpressing TMPRSS4.
Keyword
2-HydroxydiarylamideAntitumorInvasionTMPRSS4 inhibitors
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2013.01.055
Type
Article
Appears in Collections:
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.