Anti-proliferative effect of honokiol in oral squamous cancer through the regulation of specificity protein 1

Cited 28 time in scopus
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Title
Anti-proliferative effect of honokiol in oral squamous cancer through the regulation of specificity protein 1
Author(s)
D W Kim; S M Ko; Young Joo Jeon; Y W Noh; N J Choi; S D Cho; H S Moon; Y S Cho; J C Shin; S M Park; K S Seo; Ji Young Choi; J I Chae; J H Shim
Bibliographic Citation
International Journal of Oncology, vol. 43, no. 4, pp. 1103-1110
Publication Year
2013
Abstract
Honokiol (HK), a novel plant-derived natural product, is a physiologically activated compound with polyphenolic structure, and has been identified to function as an anticancer agent. It has been widely used in several diseases as a traditional medicine for a long time. We investigated whether HK could show anticancer effects on two oral squamous cell lines (OSCCs), HN-22 and HSC-4. We demonstrated that HK-treated cells showed dramatic reduction in cell growth and apoptotic cell morphologies. Intriguingly, the transcription factor specificity protein 1 (Sp1) was significantly inhibited by HK in a dose-dependent manner. Furthermore, we checked changes in cell cycle regulatory proteins and anti-apoptotic proteins at the molecular level, which are known as Sp1 target genes. The important key regulators in the cell cycle such as p27 and p21 were up-regulated by HK-mediated down-regulation of Sp1, whereas anti-apoptotic proteins including Mcl-1 and survivin were decreased, resulting in caspase-dependent apoptosis. Taken together, results from this study suggest that HK could modulate Sp1 transactivation and induce apoptotic cell death through the regulation of cell cycle and suppression of anti apoptotic proteins. In addition, HK may be used in cancer prevention and therapies to improve the clinical outcome as an anticancer drug.
Keyword
ApoptosisHonokiolOral squamous cancer cellSpecificity protein 1
ISSN
1019-6439
Publisher
Spandidos Publ Ltd
DOI
http://dx.doi.org/10.3892/ijo.2013.2028
Type
Article
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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