A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases

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Title
A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases
Author(s)
H Liu; K Liu; Z Huang; Chan-Mi Park; N R Thimmegowda; Jae-Hyuk JangInJa Ryoo; L He; Sun Ok Kim; N Oi; K W Lee; Nak Kyun Soung; A M Bode; Y Yang; X Zhou; R L Erikson; Jong Seog AhnJoonsung Hwang; K E Kim; Z Dong; Bo Yeon Kim
Bibliographic Citation
Journal of Biological Chemistry, vol. 288, no. 36, pp. 25924-25937
Publication Year
2013
Abstract
Background: Binding to the ATP site results in poor selectivity; therefore, development of ATP-noncompetitive inhibitors is needed. Results: A modified chrysin with anticancer activity targets Cdks and binds to a Cdk2 allosteric site, not the ATP pocket. Conclusion: Modified chrysin is a novel ATP-noncompetitive inhibitor. Significance: This pharmacophore model might provide insights for the development of new ATP-noncompetitive agents
ISSN
0021-9258
Publisher
Amer Soc Biochemistry Molecular Biology Inc
DOI
http://dx.doi.org/10.1074/jbc.M113.464669
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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