The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 and Bcl-2-associated athanogene domain 3 expression by blocking heat shock factor 1 binding to promoters = HSF1 promoter 결합 저해로 HSP70과 BAG3 억제
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- Title
- The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 and Bcl-2-associated athanogene domain 3 expression by blocking heat shock factor 1 binding to promoters = HSF1 promoter 결합 저해로 HSP70과 BAG3 억제
- Author(s)
- Joo Ae Kim; Youngmi Kim; Byoung-Mog Kwon; Dong Cho Han
- Bibliographic Citation
- Journal of Biological Chemistry, vol. 288, no. 40, pp. 28713-28726
- Publication Year
- 2013
- Abstract
- Background:HSF1 is a transcription factor that enhances cancer formation and progression. Results:Cantharidin inhibited the binding of HSF1 to theHSP70promoter and subsequently blocked HSF1-dependentHSP70 expression. Conclusion:The HSF1-dependent expression of HSP70 and BAG3 is inhibited by cantharidin, causing the down-regulation of antiapoptotic BCL-2 family proteins, especially MCL-1. Significance:This information provides a new target molecule and pathway of cantharidin.
- ISSN
- 0021-9258
- Publisher
- Amer Soc Biochemistry Molecular Biology Inc
- DOI
- http://dx.doi.org/10.1074/jbc.M113.488346
- Type
- Article
- Appears in Collections:
- Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
- Files in This Item:
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