Bisabolangelone inhibits dendritic cell functions by blocking MAPK and NF-kappa B signaling

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Title
Bisabolangelone inhibits dendritic cell functions by blocking MAPK and NF-kappa B signaling
Author(s)
H S Kim; Y J Lee; H K Lee; J S Kim; Y Park; Jong Soon Kang; B Y Hwang; J T Hong; Y Kim; S B Han
Bibliographic Citation
Food and Chemical Toxicology, vol. 59, pp. 26-33
Publication Year
2013
Abstract
Bisabolangelone (BISA), isolated from the roots of Angelica koreana, has many pharmacological activities, such as anti-tumor, anti-microbial, antioxidant, and anti-inflammatory activities. In this study, we investigated the anti-inflammatory mechanisms of BISA in dendritic cells (DCs), which play an essential role in innate and adaptive immune responses. BISA attenuated the production of pro-inflammatory cytokines including interleukin (IL)-12, IL-1β, and tumor necrosis factor-alpha (TNF-α), migration to macrophage inflammatory protein-3 beta, and allo-T cell activating ability of DCs. In addition, BISA affected endocytosis of DCs. Molecular studies showed that BISA suppressed MAPK phosphorylation and nuclear translocation of NF-κB p50/p65. Taken together, our data suggest that BISA inhibited DC functions by blocking MAPK and NF-κB signaling.
Keyword
BisabolangeloneDendritic cellsMAPKsNF-κB
ISSN
0278-6915
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.fct.2013.05.013
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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