CD27 engagement by a soluble CD70 protein enhances non-cytolytic antiviral activity of CD56bright natural killer cells by IFN-γ secretion

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Title
CD27 engagement by a soluble CD70 protein enhances non-cytolytic antiviral activity of CD56bright natural killer cells by IFN-γ secretion
Author(s)
Y S Jang; W Kang; D Y Chang; P S Sung; Bum Chan Park; S H Yoo; Young Woo Park; E C Shin
Bibliographic Citation
Clinical Immunology, vol. 149, no. 3, pp. 379-387
Publication Year
2013
Abstract
We investigated regulation of human NK cell function by CD27 engagement using a recombinant soluble CD70 protein. CD27 was preferentially expressed on CD56bright NK cells, and soluble CD70 protein bound to CD27+CD56bright NK cells. While soluble CD70 protein enhanced IFN-γ secretion by CD56bright NK cells in the presence of IL-12, it augmented neither cytolytic activity nor proliferation of NK cells. Thus, we next asked if soluble CD70 protein could be used to induce non-cytolytic antiviral activity of NK cells using an in vitro hepatitis C virus (HCV) infection system. Soluble CD70 protein stimulated NK cells to suppress HCV replication by enhancing NK cell IFN-γ secretion without killing infected cells. Taken together, we demonstrate that CD27 engagement by a soluble CD70 protein enhances non-cytolytic antiviral activity of CD56bright NK cells by IFN-γ secretion. Thus, this soluble CD70 protein may be useful for the treatment of viral infections such as HCV infection.
Keyword
CD27CD70Hepatitis C virusIFN-γNatural killer cells
ISSN
1521-6616
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.clim.2013.09.007
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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