Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway

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Title
Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway
Author(s)
Kyu-Sun Lee; Z Wu; Y Song; S S Mitra; A H Feroze; S H Cheshier; B Lu
Bibliographic Citation
Genes & Development, vol. 27, no. 24, pp. 2642-2647
Publication Year
2013
Abstract
The self-renewal versus differentiation choice of Drosophila and mammalian neural stem cells (NSCs) requires Notch (N) signaling. How N regulates NSC behavior is not well understood. Here we show that canonical N signaling cooperates with a noncanonical N signaling pathway to mediate N-directed NSC regulation. In the noncanonical pathway, N interacts with PTEN-induced kinase 1 (PINK1) to influence mitochondrial function, activating mechanistic target of rapamycin complex 2 (mTORC2)/AKT signaling. Importantly, attenuating noncanonical N signaling preferentially impaired the maintenance of Drosophila and human cancer stem cell-like tumor-forming cells. Our results emphasize the importance of mitochondria to N and NSC biology, with important implications for diseases associated with aberrant N signaling.
Keyword
Cancer stem cellsMitochondriamTORC2/AKT signalingNeural stem cellsNotchPINK1
ISSN
0890-9369
Publisher
Cold Spring Harbor Lab Press, Publications Dept
DOI
http://dx.doi.org/10.1101/gad.225169.113
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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