Metabolite changes signal genetic regulatory mechanisms for robust cell behavior

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Title
Metabolite changes signal genetic regulatory mechanisms for robust cell behavior
Author(s)
Sang Jun Lee; A Trostel; S Adhya
Bibliographic Citation
Mbio, vol. 5, no. 1, pp. e00972-e00972
Publication Year
2014
Abstract
Exploiting mechanisms of utilizing the sugar D-galactose in Escherichia coli as a model system, we explored the consequences of accumulation of critical intermediates of the D-galactose metabolic pathways by monitoring cell growth, metabolites, and transcript profiles. These studies revealed both metabolic network changes far from the D-galactose pathway and changes in the global gene regulatory network. The concentration change of a critical intermediate disturbs the equilibrium state, generating a ripple effect through several metabolic pathways that ends up signaling up- or downregulation of specific sets of genes in a programmed manner to cope with the imbalance. Such long-range effects on metabolites and genetic regulatory mechanisms not only may be a common feature in bacteria but very likely operate during cellular development and differentiation in higher organisms as well as in disease cells, like cancer cells
ISSN
2150-7511
Publisher
Amer Soc Microb
DOI
http://dx.doi.org/10.1128/mBio.00972-13
Type
Article
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1. Journal Articles > Journal Articles
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