Structural modeling of Vpu from HIV-1 based on solid-state NMR observables

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Title
Structural modeling of Vpu from HIV-1 based on solid-state NMR observables
Author(s)
Seon Joo Ahn; Gyu Tae Lim; S Nam; Jinhyuk Lee
Bibliographic Citation
Chemical Physics Letters, vol. 599, pp. 116-121
Publication Year
2014
Abstract
Vpu is one of the accessory proteins of HIV-1, and is involved in viral particle release. Viral particle release is enhanced by two proposed functions of Vpu: (i) tetherin interaction and (ii) membrane polarization. Two Vpu functions in viral particle release are still controversial. Here, we investigated the proposed functions by extensive structural modeling of Vpu based on solid-state NMR (Nuclear Magnetic Resonance) observables. We found that Vpu can co-exist in two structural forms: left-handed and right-handed conformation. The co-existence of the two conformations provides a clue to reconcile the controversial issue of its two functions in virus particle release.
ISSN
0009-2614
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.cplett.2014.03.033
Type
Article
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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