Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging

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Title
Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging
Author(s)
Eun Kyung Lim; B Kang; Y Choi; E Jang; S Han; K Lee; J S Suh; S Haam; Y M Huh
Bibliographic Citation
Nanotechnology, vol. 25, no. 24, pp. 245103-245103
Publication Year
2014
Abstract
We developed Pyrene-Gadolinium (Py-Gd) nanoparticles as pH-sensitive magnetic resonance imaging (MRI) contrast agents capable of showing a high-Mr signal in cancer-specific environments, such as acidic conditions. Py-Gd nanoparticles were prepared by coating Py-Gd, which is a complex of gadolinium with pyrenyl molecules, with pyrenyl polyethyleneglycol PEG using a nano-emulsion method. These particles show better longitudinal relaxation time (T1) MR signals in acidic conditions than they do in neutral conditions. Furthermore, the particles exhibit biocompatibility and MR contrast effects in both in vitro and in vivo studies. From these results, we confirm that Py-Gd nanoparticles have the potential to be applied for accurate cancer diagnosis and therapy.
Keyword
gadoliniumhigh sensitivityimaging agentmagnetic resonance image
ISSN
0957-4484
Publisher
IOP Publishing Ltd
DOI
http://dx.doi.org/10.1088/0957-4484/25/24/245103
Type
Article
Appears in Collections:
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
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