Violapyrones H and I, new cytotoxic compounds isolated from Streptomyces sp. associated with the marine starfish Acanthaster planci

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Title
Violapyrones H and I, new cytotoxic compounds isolated from Streptomyces sp. associated with the marine starfish Acanthaster planci
Author(s)
H J Shin; H S Lee; J S Lee; J Shin; M A Lee; H S Lee; Y J Lee; Jieun Yun; Jong Soon Kang
Bibliographic Citation
Marine Drugs, vol. 12, no. 6, pp. 3283-3291
Publication Year
2014
Abstract
Two new α-pyrone derivatives, violapyrones H (1) and I (2), along with known violapyrones B (3) and C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived from a crown-of-thorns starfish, Acanthaster planci, collected from Chuuk, Federated States of Micronesia. The structures of violapyrones were elucidated by the analysis of 1D and 2D NMR and HR-ESIMS data. Violapyrones (1-4) exhibited cytotoxicity against 10 human cancer cell lines with GI50 values of 1.10-26.12 μg/mL when tested using sulforhodamine B (SRB) assay. This is the first report on the cytotoxicity of violapyrones against cancer cell lines and the absolute configuration of violapyrone C.
Keyword
Anti-cancer activityStarfishStreptomyces sp.Violapyronesα-pyrones
ISSN
1660-3397
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/md12063283
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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