One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging

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Title
One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging
Author(s)
A Kukreja; Eun Kyung Lim; B Kang; Y Choi; T Lee; J S Suh; Y M Huh; S Haam
Bibliographic Citation
International Journal of Nanomedicine, vol. 9, no. 1, pp. 2489-2498
Publication Year
2014
Abstract
In this study, dextran-encrusted magnetic nanoclusters (DMNCs) were synthesized using a one-pot solution phase method for detection of atherosclerosis by magnetic resonance imaging. Pyrenyl dextran was used as a surfactant because of its electron-stabilizing effect and its amphiphilic nature, rendering the DMNCs stable and water-dispersible. The DMNCs were 65.6±4.3 nm, had a narrow size distribution, and were superparamagnetic with a high magnetization value of 60.1 emu/g. Further, they showed biocompatibility and high cellular uptake efficiency, as indicated by a strong interaction between dextran and macrophages. In vivo magnetic resonance imaging demonstrated the ability of DMNCs to act as an efficient magnetic resonance imaging contrast agent capable of targeted detection of atherosclerosis. In view of these findings, it is concluded that DMNCs can be used as magnetic resonance imaging contrast agents to detect inflammatory disease.
Keyword
AtherosclerosisDextranMacrophagesMagnetic nanocrystalMagnetic resonance imaging
ISSN
1178-2013
Publisher
Dove Medical Press Ltd
DOI
http://dx.doi.org/10.2147/IJN.S55525
Type
Article
Appears in Collections:
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
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