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- Title
- The lactone form of stachybotrydial: a new inhibitor of dihydrofolate reductase from Stachybotrys sp. FN298
- Author(s)
- Yun Ju Kwon; Mi-Jin Sohn; Hyun Ju Kim; Won Gon Kim
- Bibliographic Citation
- Biological & Pharmaceutical Bulletin, vol. 37, no. 8, pp. 1406-1410
- Publication Year
- 2014
- Abstract
- Dihydrofolate reductase (DHFR) has been confirmed to be a novel target for antibacterial drug development. In this study, we determined that a fungal metabolite from Stachybotrys sp. FN298 can inhibit the DHFR of Staphylococcus aureus. Its structure was identified as a lactone form of stachybotrydial using mass spectrometry and nuclear magnetic resonance analysis. This compound inhibited S. aureus DHFR with a half-maximal inhibitory concentration of 41 μM. It also prevented the growth of S. aureus and methicillinresistant S. aureus (MRSA) with a minimum inhibitory concentration of 32 μg?mL-1. To our knowledge, this is the first description of a DHFR inhibitor of microbial origin. The inhibitory function of the lactone form of stachybotrydial highlights its potential for development into a new broad-spectrum antibacterial agent and as an agent against MRSA.
- Keyword
- Dihydrofolate reductaseStachybotrydialStachybotrysStaphylococcus aureus
- ISSN
- 0918-6158
- Publisher
- Pharmaceutical Soc Japan
- DOI
- http://dx.doi.org/10.1248/bpb.b14-00108
- Type
- Article
- Appears in Collections:
- Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
- Files in This Item:
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