Tussilagone inhibits dendritic cell functions via induction of heme oxygenase-1

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Title
Tussilagone inhibits dendritic cell functions via induction of heme oxygenase-1
Author(s)
Y Park; H S Ryu; H K Lee; J S Kim; Ji Eun Yun; Jong Soon Kang; B Y Hwang; J T Hong; Y Kim; S B Han
Bibliographic Citation
International Immunopharmacology, vol. 22, no. 2, pp. 400-408
Publication Year
2014
Abstract
Sesquiterpenoid tussilagone (TUS) has a variety of pharmacological activities, such as anti-oxidant, anti-cancer, and anti-inflammatory activities. In this study, we investigated the effects of TUS on dendritic cell (DC) functions and the underlying mechanisms. TUS inhibited lipopolysaccharide (LPS)-induced activation of DCs, as shown by decrease in surface molecule expression, cytokine production, cell migration, and allo-T cell activation. In addition, TUS inhibited LPS-induced activation of NF-κB, MAPKs, and IRF-3 signalings in DCs, although it did not directly affect kinase activities of IRAK1/4, TAK1, and IKK, which suggests that TUS might indirectly inhibit TLR signaling in DCs. As a critical mechanism, we showed that TUS activated heme oxygenase-1 (HO-1), which degrades heme to immunosuppressive products, such as carbon monoxide and bilirubin. HO-1 inhibitor reversed the inhibitory activity of TUS in DCs. In conclusion, this study suggests that TUS inhibits DC function through the induction of HO-1.
Keyword
Dendritic cellsHeme oxygenase-1MAPKsNF-κBTussilagone
ISSN
1567-5769
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.intimp.2014.07.023
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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