Subcellular neural probes from single-crystal gold nanowires

Cited 44 time in scopus
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Title
Subcellular neural probes from single-crystal gold nanowires
Author(s)
M Kang; S Jung; H Zhang; Taejoon Kang; H Kang; Y Yoo; J P Hong; J P Ahn; J Kwak; D Jeon; N A Kotov; B Kim
Bibliographic Citation
ACS Nano, vol. 8, no. 8, pp. 8182-8189
Publication Year
2014
Abstract
Size reduction of neural electrodes is essential for improving the functionality of neuroprosthetic devices, developing potent therapies for neurological and neurodegenerative diseases, and long-term brain-computer interfaces. Typical neural electrodes are micromanufactured devices with dimensions ranging from tens to hundreds of micrometers. Their further miniaturization is necessary to reduce local tissue damage and chronic immunological reactions of the brain. Here we report the neural electrode with subcellular dimensions based on single-crystalline gold nanowires (NWs) with a diameter of ∼100 nm. Unique mechanical and electrical properties of defect-free gold NWs enabled their implantation and recording of single neuron-activities in a live mouse brain despite a ∼50× reduction of the size compared to the closest analogues. Reduction of electrode dimensions enabled recording of neural activity with improved spatial resolution and differentiation of brain activity in response to different social situations for mice. The successful localization of the epileptic seizure center was also achieved using a multielectrode probe as a demonstration of the diagnostics potential of NW electrodes. This study demonstrated the realism of single-neuron recording using subcellular-sized electrodes that may be considered a pivotal point for use in diverse studies of chronic brain diseases.
Keyword
BRAIN initiativebrain-machine interfaceelectrode miniaturizationepilepsygold nanowirelong-term neural recordingsnanoelectrodeneural implantsneurodegenerative diseaseneuroprostheticsparalysissingle-neuron detectionsubcellular-sized implants
ISSN
1936-0851
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/nn5024522
Type
Article
Appears in Collections:
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
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