Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion

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Title
Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion
Author(s)
M J Jang; Ye Sol Kim; E Y Bae; T S Oh; H J Choi; J H Lee; Hyun-Mee Oh; Seung Woong Lee
Bibliographic Citation
Molecules, vol. 19, no. 12, pp. 20340-20349
Publication Year
2014
Abstract
Three saikosaponins were isolated from the MeOH extract of the roots of Bupleurum falcatum L.: saikosaponins B3 (1); B4 (2); and D ( 3). Of the three, compound 3 inhibited the interaction of selectins (E, L, and P) and THP-1 cells with IC50 values of 1.8, 3.0 and 4.3 μM, respectively. Also, the aglycone structure 4 of compound 3 showed moderate inhibitory activity on L-selectin-mediated cell adhesion. From these results, we suspect that compound 3 isolated from Bupleurum falcatum roots would be a good candidate for therapeutic strategies to treat inflammation.
Keyword
Anti-inflammatory agentsBupleurum falcatum lCell adhesion moleculesSaikosaponinSelectinTriterpenoid saponin
ISSN
1420-3049
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/molecules191220340
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
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