Open Access@KRIBBDivision of Research on National ChallengesBionanotechnology Research Center1. Journal Articles
Smart nanoprobes for the detection of alkaline phosphatase activity during osteoblast differentiation
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- Title
- Smart nanoprobes for the detection of alkaline phosphatase activity during osteoblast differentiation
- Author(s)
- Eun Kyung Lim; Joo Oak Keem; H S Yun; Jin Young Jeong; Bong Hyun Chung
- Bibliographic Citation
- Chemical Communications, vol. 51, no. 15, pp. 3270-3272
- Publication Year
- 2015
- Abstract
- Gold nanoparticle-conjugated fluorescent hydroxyapatite (AuFHAp) was developed as a smart nanoprobe for measuring alkaline phosphatase (ALP) activity. AuFHAp showed NIR fluorescence due to the hydrolysis of its phosphate groups by ALP. In addition, gold nanoparticles help reduce the nonspecific signal by absorbing nonspecific fluorescence. Through in vitro tests, we confirmed that the AuFHAp probe was capable of detecting ALP levels related to osteoblast activity in living cells with high fluorescence intensity.
- ISSN
- 1359-7345
- Publisher
- Royal Soc Chem
- Full Text Link
- http://dx.doi.org/10.1039/c4cc09620g
- Type
- Article
- Appears in Collections:
- Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
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