Inhibition of diacylglycerol acyltransferase by prenylated flavonoids isolated from the stem bark of Maackia amurensis

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Title
Inhibition of diacylglycerol acyltransferase by prenylated flavonoids isolated from the stem bark of Maackia amurensis
Author(s)
N Li; N Zhang; J L Li; P G Du; Hyun Sun Lee; L Cui
Bibliographic Citation
Journal of Asian Natural Products Research, vol. 17, no. 2, pp. 178-181
Publication Year
2015
Abstract
A new prenylated flavanone, erythraddison Z (1), together with eight known flavonoids (2-9), was isolated from the stem bark of Maackia amurensis. Their structures were elucidated on the basis of spectroscopic methods, including 1D and 2D NMR (COSY, HMQC, and HMBC) techniques. All the isolates, with the exception of 3, 6 and 7, strongly inhibited diacylglycerol acyltransferase activity in an in vitro assay with IC50 values ranging from 96.5 ± 0.6 to 135.1 ± 1.4 M.
Keyword
DGATLeguminosaeMaackia amurensisprenylated flavanone
ISSN
1028-6020
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.1080/10286020.2014.960402
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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