Mammalian polo-like Kinase 1 (Plk1) promotes proper chromosome segregation by phosphorylating and delocalizing the PBIP1·CENP-Q complex from kinetochores
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- Title
- Mammalian polo-like Kinase 1 (Plk1) promotes proper chromosome segregation by phosphorylating and delocalizing the PBIP1·CENP-Q complex from kinetochores
- Author(s)
- C H Park; J E Park; T S Kim; Y H Kang; Nak Kyun Soung; M Zhou; N H Kim; J K Bang; K S Lee
- Bibliographic Citation
- Journal of Biological Chemistry, vol. 290, no. 13, pp. 8569-8581
- Publication Year
- 2015
- Abstract
- Background: Plk1 is a protein kinase that localizes to subcellular structures called kinetochores to promote mitotic progression. Results: Plk1 interacts with and regulates a kinetochore-associated PBIP1·CENP-Q complex. Conclusion: This is a tightly regulated, cell cycle-dependent process, the deregulation of which leads to improper chromosome segregation and mitotic progression. Significance: This event is likely critical for maintaining genomic integrity and preventing aneuploidy.
- ISSN
- 0021-9258
- Publisher
- Amer Soc Biochemistry Molecular Biology Inc
- Full Text Link
- http://dx.doi.org/10.1074/jbc.M114.623546
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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