Mammalian polo-like Kinase 1 (Plk1) promotes proper chromosome segregation by phosphorylating and delocalizing the PBIP1·CENP-Q complex from kinetochores

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Title
Mammalian polo-like Kinase 1 (Plk1) promotes proper chromosome segregation by phosphorylating and delocalizing the PBIP1·CENP-Q complex from kinetochores
Author(s)
C H Park; J E Park; T S Kim; Y H Kang; Nak Kyun Soung; M Zhou; N H Kim; J K Bang; K S Lee
Bibliographic Citation
Journal of Biological Chemistry, vol. 290, no. 13, pp. 8569-8581
Publication Year
2015
Abstract
Background: Plk1 is a protein kinase that localizes to subcellular structures called kinetochores to promote mitotic progression. Results: Plk1 interacts with and regulates a kinetochore-associated PBIP1·CENP-Q complex. Conclusion: This is a tightly regulated, cell cycle-dependent process, the deregulation of which leads to improper chromosome segregation and mitotic progression. Significance: This event is likely critical for maintaining genomic integrity and preventing aneuploidy.
ISSN
0021-9258
Publisher
Amer Soc Biochemistry Molecular Biology Inc
DOI
http://dx.doi.org/10.1074/jbc.M114.623546
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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