Curcumin mitigates accelerated aging after irradiation in drosophila by reducing oxidative stress

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Title
Curcumin mitigates accelerated aging after irradiation in drosophila by reducing oxidative stress
Author(s)
K M Seong; M Yu; Kyu-Sun Lee; S Park; Y W Jin; K J Min
Bibliographic Citation
Biomed Research International, vol. 2015, pp. 425380-425380
Publication Year
2015
Abstract
Curcumin, belonging to a class of natural phenol compounds, has been extensively studied due to its antioxidative, anticancer, anti-inflammatory, and antineurodegenerative effects. Recently, it has been shown to exert dual activities after irradiation, radioprotection, and radiosensitization. Here, we investigated the protective effect of curcumin against radiation damage using D. melanogaster. Pretreatment with curcumin (100 M) recovered the shortened lifespan caused by irradiation and increased eclosion rate. Flies subjected to high-dose irradiation showed a mutant phenotype of outstretched wings, whereas curcumin pretreatment reduced incidence of the mutant phenotype. Protein carbonylation and formation of γ H2Ax foci both increased following high-dose irradiation most likely due to generation of reactive oxygen species. Curcumin pretreatment reduced the amount of protein carbonylation as well as formation of γ H2Ax foci. Therefore, we suggest that curcumin acts as an oxidative stress reducer as well as an effective protective agent against radiation damage.
ISSN
2314-6133
Publisher
Hindawi Ltd
DOI
http://dx.doi.org/10.1155/2015/425380
Type
Article
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1. Journal Articles > Journal Articles
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