MED30 regulates the proliferation and motility of gastric cancer cells

Cited 7 time in scopus
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Title
MED30 regulates the proliferation and motility of gastric cancer cells
Author(s)
Y J Lee; M E Han; S J Baek; Seon-Young Kim; S O Oh
Bibliographic Citation
PLoS One, vol. 10, no. 6, pp. e0130826-e0130826
Publication Year
2015
Abstract
MED30 is an essential member of the mediator complex that forms a hub between transcriptional activators and RNA polymerase II. However, the expressions and roles of MED30 have been poorly characterized in cancer. In this study, we examined the functional roles of MED30 during gastric cancer progression. It was found that MED30 was overexpressed in gastric cancer tissues and cell lines. Moreover, MED30 overexpression increased the proliferation, migration, and invasion of gastric cancer cells, whereas MED30 knockdown inhibited these effects. Furthermore the knockdown significantly inhibited tumorigenicity in SCID mice. MED30 also promoted the expressions of genes related to epithelial-mesenchymal transition and induced a fibroblast-like morphology. This study shows MED30 has pathophysiological roles in the proliferation, migration, and invasion of gastric cancer cells and suggests that MED30 should be viewed as a potent therapeutic target for malignant gastric carcinoma
ISSN
1932-6203
Publisher
Public Library of Science
DOI
http://dx.doi.org/10.1371/journal.pone.0130826
Type
Article
Appears in Collections:
Korea Bioinformation Center > 1. Journal Articles
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