Network comparison of inflammation in colorectal cancer and Alzheimer's disease

Cited 2 time in scopus
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Title
Network comparison of inflammation in colorectal cancer and Alzheimer's disease
Author(s)
S Park; S J Yu; Y Cho; C Balch; Jinhyuk Lee; Y H Kim; S Nam
Bibliographic Citation
Biomed Research International, vol. 2015, pp. 205247-205247
Publication Year
2015
Abstract
Recently, a large clinical study revealed an inverse correlation of individual risk of cancer versus Alzheimer's disease (AD). However, no explanation exists for this anticorrelation at the molecular level; however, inflammation is crucial to the pathogenesis of both diseases, necessitating a need to understand differing signaling usage during inflammatory responses distinct to both diseases. Using a subpathway analysis approach, we identified numerous well-known and previously unknown pathways enriched in datasets from both diseases. Here, we present the quantitative importance of the inflammatory response in the two disease pathologies and summarize signal transduction pathways common to both diseases that are affected by inflammation.
ISSN
2314-6133
Publisher
Hindawi Ltd
DOI
http://dx.doi.org/10.1155/2015/205247
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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