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- Title
- Roles of mTOR signaling in brain development
- Author(s)
- Da Yong Lee
- Bibliographic Citation
- Experimental Neurobiology, vol. 24, no. 3, pp. 177-185
- Publication Year
- 2015
- Abstract
- mTOR is a serine/threonine kinase composed of multiple protein components. Intracellular signaling of mTOR complexes is involved in many of physiological functions including cell survival, proliferation and differentiation through the regulation of protein synthesis in multiple cell types. During brain development, mTOR-mediated signaling pathway plays a crucial role in the process of neuronal and glial differentiation and the maintenance of the stemness of neural stem cells. The abnormalities in the activity of mTOR and its downstream signaling molecules in neural stem cells result in severe defects of brain developmental processes causing a significant number of brain disorders, such as pediatric brain tumors, autism, seizure, learning disability and mental retardation. Understanding the implication of mTOR activity in neural stem cells would be able to provide an important clue in the development of future brain developmental disorder therapies.
- Keyword
- mTORneurogenesisgliogenesisneural stem cellpediatric brain tumorsbrain developmental disorders
- ISSN
- 1226-2560
- Publisher
- Korea Soc-Assoc-Inst
- Full Text Link
- http://dx.doi.org/10.5607/en.2015.24.3.177.
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
- Files in This Item:
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