An ultrasensitive, selective, multiplexed superbioelectronic nose that mimics the human sense of smell

Cited 78 time in scopus
Metadata Downloads
Title
An ultrasensitive, selective, multiplexed superbioelectronic nose that mimics the human sense of smell
Author(s)
Oh Seok Kwon; H S Song; S J Park; S H Lee; J H An; J W Park; H Yang; H Yoon; J Bae; T H Park; J Jang
Bibliographic Citation
Nano Letters, vol. 15, no. 10, pp. 6559-6567
Publication Year
2015
Abstract
Human sensory-mimicking systems, such as electronic brains, tongues, skin, and ears, have been promoted for use in improving social welfare. However, no significant achievements have been made in mimicking the human nose due to the complexity of olfactory sensory neurons. Combinational coding of human olfactory receptors (hORs) is essential for odorant discrimination in mixtures, and the development of hOR-combined multiplexed systems has progressed slowly. Here, we report the first demonstration of an artificial multiplexed superbioelectronic nose (MSB-nose) that mimics the human olfactory sensory system, leading to high-performance odorant discriminatory ability in mixtures. Specifically, portable MSB-noses were constructed using highly uniform graphene micropatterns (GMs) that were conjugated with two different hORs, which were employed as transducers in a liquid-ion gated field-effect transistor (FET). Field-induced signals from the MSB-nose were monitored and provided high sensitivity and selectivity toward target odorants (minimum detectable level: 0.1 fM). More importantly, the potential of the MSB-nose as a tool to encode hOR combinations was demonstrated using principal component analysis.
Keyword
field-effect transistorgraphene micropatternshuman mimickingMultiplexed bioelectronic noseodorant discriminationolfactory receptor
ISSN
1530-6984
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/acs.nanolett.5b02286
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.