Prdm4 induction by the small molecule butein promotes white adipose tissue browning = 백색지방의 갈색지방화를 조절하는 저분자물질 butein에 의해 발현된 Prdm4

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Title
Prdm4 induction by the small molecule butein promotes white adipose tissue browning = 백색지방의 갈색지방화를 조절하는 저분자물질 butein에 의해 발현된 Prdm4
Author(s)
N J Song; S Choi; P Rajbhandari; S H Chang; S Kim; L Vergnes; S M Kwon; J H Yoon; S Lee; J M Ku; Jeong Soo Lee; K Reue; S H Koo; P Tontonoz; K W Park
Bibliographic Citation
Nature Chemical Biology, vol. 12, no. 7, pp. 479-481
Publication Year
2016
Abstract
Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.
ISSN
1552-4450
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/nchembio.2081
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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