Prdm4 induction by the small molecule butein promotes white adipose tissue browning = 백색지방의 갈색지방화를 조절하는 저분자물질 butein에 의해 발현된 Prdm4

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dc.contributor.authorN J Song-
dc.contributor.authorS Choi-
dc.contributor.authorP Rajbhandari-
dc.contributor.authorS H Chang-
dc.contributor.authorS Kim-
dc.contributor.authorL Vergnes-
dc.contributor.authorS M Kwon-
dc.contributor.authorJ H Yoon-
dc.contributor.authorS Lee-
dc.contributor.authorJ M Ku-
dc.contributor.authorJeong Soo Lee-
dc.contributor.authorK Reue-
dc.contributor.authorS H Koo-
dc.contributor.authorP Tontonoz-
dc.contributor.authorK W Park-
dc.date.accessioned2017-04-19T10:25:17Z-
dc.date.available2017-04-19T10:25:17Z-
dc.date.issued2016-
dc.identifier.issn1552-4450-
dc.identifier.uri10.1038/nchembio.2081ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13369-
dc.description.abstractIncreasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.-
dc.publisherSpringer-Nature Pub Group-
dc.titlePrdm4 induction by the small molecule butein promotes white adipose tissue browning = 백색지방의 갈색지방화를 조절하는 저분자물질 butein에 의해 발현된 Prdm4-
dc.title.alternativePrdm4 induction by the small molecule butein promotes white adipose tissue browning-
dc.typeArticle-
dc.citation.titleNature Chemical Biology-
dc.citation.number7-
dc.citation.endPage481-
dc.citation.startPage479-
dc.citation.volume12-
dc.contributor.affiliatedAuthorJeong Soo Lee-
dc.contributor.alternativeName송노준-
dc.contributor.alternativeName최세리-
dc.contributor.alternativeNameRajbhandari-
dc.contributor.alternativeName장세혁-
dc.contributor.alternativeName김수지-
dc.contributor.alternativeNameVergnes-
dc.contributor.alternativeName권소미-
dc.contributor.alternativeName윤정훈-
dc.contributor.alternativeName이석찬-
dc.contributor.alternativeName구진모-
dc.contributor.alternativeName이정수-
dc.contributor.alternativeNameReue-
dc.contributor.alternativeName구승회-
dc.contributor.alternativeNameTontonoz-
dc.contributor.alternativeName박계원-
dc.identifier.bibliographicCitationNature Chemical Biology, vol. 12, no. 7, pp. 479-481-
dc.identifier.doi10.1038/nchembio.2081-
dc.description.journalClassY-
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Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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