Open Access@KRIBBDivision of A.I. & Biomedical ResearchMicrobiome Convergence Research Center1. Journal Articles
Prdm4 induction by the small molecule butein promotes white adipose tissue browning = 백색지방의 갈색지방화를 조절하는 저분자물질 butein에 의해 발현된 Prdm4
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- Title
- Prdm4 induction by the small molecule butein promotes white adipose tissue browning = 백색지방의 갈색지방화를 조절하는 저분자물질 butein에 의해 발현된 Prdm4
- Author(s)
- N J Song; S Choi; P Rajbhandari; S H Chang; S Kim; L Vergnes; S M Kwon; J H Yoon; S Lee; J M Ku; Jeong Soo Lee; K Reue; S H Koo; P Tontonoz; K W Park
- Bibliographic Citation
- Nature Chemical Biology, vol. 12, no. 7, pp. 479-481
- Publication Year
- 2016
- Abstract
- Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.
- ISSN
- 1552-4450
- Publisher
- Springer-Nature Pub Group
- Full Text Link
- http://dx.doi.org/10.1038/nchembio.2081
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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