Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation = 곰보배추로부터 분리된 유데스만계 세스퀴테르페노이드 화합물의 IL-6 유도 STAT3 활성 저해

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Title
Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation = 곰보배추로부터 분리된 유데스만계 세스퀴테르페노이드 화합물의 IL-6 유도 STAT3 활성 저해
Author(s)
Hyun Jae Jang; Hyun-Mee Oh; Joo Tae Hwang; Mi Hwa Kim; Soyoung LeeKyungsook Jung; Y H Kim; Seung Woong LeeMun Chual Rho
Bibliographic Citation
Phytochemistry, vol. 130, pp. 335-342
Publication Year
2016
Abstract
Seven eudesmane-type sesquiterpenoid lactones and the known plebeiolide C were isolated from an ethanol-soluble extract of the aerial parts of Salvia plebeia R. Br. Their structures were determined via NMR and MS, and their absolute configurations were elucidated using ECD, and X-ray crystallographic analysis, as well as the modified Mosher ester method. All isolates were evaluated for their inhibitory effects on IL6-induced STAT3 promoter activation in stably transfected Hep3B cells. Of these isolates, eudebeiolide D exhibited an inhibitory effect with the IC50 value of 1.1?μM.
Keyword
Salvia plebeiaLamiaceaeEudesmane sesquiterpenoidsIL-6STAT3Inflammation
ISSN
0031-9422
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.phytochem.2016.08.001
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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