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Sesquiterpenoids from the rhizomes of Curcuma phaeocaulis and their inhibitory effects on LPS-induced TLR4 activation = 아출로부터 분리된 세스퀴테르페노이드 화합물의 TLR-4 저해활성
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- Title
- Sesquiterpenoids from the rhizomes of Curcuma phaeocaulis and their inhibitory effects on LPS-induced TLR4 activation = 아출로부터 분리된 세스퀴테르페노이드 화합물의 TLR-4 저해활성
- Author(s)
- Hyun Jae Jang; Jin Han Kim; Hyun-Mee Oh; Min Suk Kim; Jin Ha Jo; Kyungsook Jung; Soyoung Lee; Y H Kim; Woo Song Lee; Seung Woong Lee; Mun Chual Rho
- Bibliographic Citation
- Chemical & Pharmaceutical Bulletin, vol. 64, no. 7, pp. 1062-1066
- Publication Year
- 2016
- Abstract
- Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an EtOAc-soluble extract of Curcuma phaeocaulis rhizomes. The structures of the isolated compounds were elucidated using a combination of NMR, MS, and circular dichroism (CD) spectra. The inhibitory effects of each compound on lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) activation in THP-1-Blue cells were assessed, and compound 4 showed more potent inhibitory activity against LPS-stimulated TLR4 activation.
- Keyword
- ZingiberaceaeCurcuma phaeocaulisLipopolysaccharide (LPS)SesquiterpenoidToll-like receptor 4 (TLR4)
- ISSN
- 0009-2363
- Publisher
- Pharmaceutical Soc Japan
- Full Text Link
- http://dx.doi.org/10.1248/cpb.c16-00086
- Type
- Article
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