Stachybotrysin, an osteoclast differentiation inhibitor from the marine-derived fungus Stachybotrys sp. KCB13F013

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Title
Stachybotrysin, an osteoclast differentiation inhibitor from the marine-derived fungus Stachybotrys sp. KCB13F013
Author(s)
Jong Won Kim; Sung-Kyun Ko; Hye Min Kim; Gun Hee Kim; Sangkeun Son; Gil Soo Kim; Gui-Ja Hwang; Eun Soo Jeon; Kee Sun ShinIn Ja RyooYoung-Soo Hong; H Oh; Kyung Ho LeeNak Kyun Soung; D Hashizume; T Nogawa; S Takahashi; Bo Yeon Kim; H Osada; Jae-Hyuk JangJong Seog Ahn
Bibliographic Citation
Journal of Natural Products, vol. 79, no. 10, pp. 2703-2708
Publication Year
2016
Abstract
Two new phenylspirodrimane derivatives, stachybotrysin (1) and stachybotrylactone B (2), were isolated from the cultures of the marine-derived fungus Stachybotrys sp. KCB13F013. The structures were determined by analyzing the spectroscopic data (1D and 2D NMR and MS) and chemical transformation, including the modified Mosher's method and single-crystal X-ray structure analysis. Compound 1 exhibited an inhibitory effect on osteoclast differentiation in bone marrow macrophage cells via suppressing the RANKL-induced activation of p-ERK, p-JNK, p-p38, c-Fos, and NFATc1.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/acs.jnatprod.6b00641
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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