A study on the evaluation of the PLGA-curcumin treated rat models for osteoporosis improvement using finite element analysis

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Title
A study on the evaluation of the PLGA-curcumin treated rat models for osteoporosis improvement using finite element analysis
Author(s)
S K Han; M J Sung; J Ahn; Jin Young Jeong; H S Yun; Chang-Soo Lee; C Ko
Bibliographic Citation
Journal of Mechanics in Medicine and Biology, vol. 17, no. 4, pp. 1750050-1750050
Publication Year
2017
Abstract
Osteoporosis induced bone fracture is not limited to simple damage according to its fractured region and the age of the damaged person. Therefore, there has been more necessity to understand and study the biomechanical aspects of osteoporosis, and relevant research has actively been conducted. With the development of medical imaging technology, the reconstruction of CT images into a 3D model has been made possible, and it has been conducted to analyze 3-dimensionally and inhomogeneously distributed bone mineral density according to CT values. The 3D bone strength computational analysis based on 2D bone images utilized for evaluating the new treatment using the mixture of PLGA and curcumin for rat osteoporosis model. After the treatment, bone mineral density recovered by 65% compared to the osteoporosis model, moreover, bone strength improved by 113%. This study suggested that the limitations of conventional bone monitoring method using 2D bone images can be overcome by considering 3D bone computational analysis. It is considered that introducing the newly proposed Deformation Per Volume (DPW) and Stress Per Weight (SPW) can be also used as effective parameters to more accurately predict the change in bone stiffness.
Keyword
3D computational analysisbone strengthOsteoporosisrat osteoporosis model
ISSN
0219-5194
Publisher
World Scientific Publ Co Pte Ltd
DOI
http://dx.doi.org/10.1142/S0219519417500506
Type
Article
Appears in Collections:
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Division of Biomaterials Research > Bionanotechnology Research Center > 1. Journal Articles
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