Beneficial effects of pterocarpan-high soybean leaf extract on metabolic syndrome in overweight and obese Korean subjects: randomized controlled trial

Cited 9 time in scopus
Metadata Downloads
Title
Beneficial effects of pterocarpan-high soybean leaf extract on metabolic syndrome in overweight and obese Korean subjects: randomized controlled trial
Author(s)
R Ryu; Tae Sook Jeong; Y J Kim; J Y Choi; S J Cho; E Y Kwon; U J Jung; Hyeon Seon Ji; D H Shin; M S Choi
Bibliographic Citation
Nutrients, vol. 8, pp. 734-734
Publication Year
2016
Abstract
Pterocarpans are known to have antifungal and anti-inflammatory properties. However, little is known about the changes in transcriptional profiles in response to a pterocarpan-high soybean leaf extract (PT). Therefore, this study investigated the effects of PT on blood glucose and lipid levels, as well as on the inflammation-related gene expression based on a peripheral blood mononuclear cells (PBMCs) mRNA sequencing analysis in Korean overweight and obese subjects with mild metabolic syndrome. The participants were randomly assigned to two groups and were administered either placebo (starch, 3 g/day) or PT (2 g/day) for 12 weeks. The PT intervention did not change body weight, body fat percentage and body mass index (BMI). However, PT significantly decreased the glycosylated hemoglobin (HbA1c), plasma glucose, free fatty acid, total cholesterol, and non-HDL cholesterol levels after 12 weeks. Furthermore, PT supplementation significantly lowered the homeostatic index of insulin resistance, as well as the plasma levels of inflammatory markers. Finally, the mRNA sequencing analysis revealed that PT downregulated genes related to immune responses. PT supplementation is beneficial for the improvement of metabolic syndrome by altering the fasting blood and plasma glucose, HbA1c, plasma lipid levels and inflammation-related gene expression in PBMCs.
Keyword
InflammationMetabolic syndromeMRNA sequencingPBMCsSoybean leaf
ISSN
2072-6643
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/nu8110734
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
Files in This Item:

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.