Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model

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Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model
Tae-Shin Park; Young-Kyoung Ryu; Hye-Yeon Park; J Y Kim; Jun Go; Jung Ran NohYong-Hoon KimJung Hwan HwangDong Hee Choi; W K Oh; Chul Ho LeeKyoung Shim Kim
Bibliographic Citation
International Journal of Molecular Medicine, vol. 39, no. 1, pp. 21-30
Publication Year
Humulus japonicus Siebold and Zucc. (HJ) has traditionally been administered to patients with pulmonary disease, skin disease and hypertension in Korea, and it is considered to exert anti-inflammatory, antioxidant, antimicrobial and antimycobacterial effects. However, its effects against Alzheimer's disease (AD) have yet to be explored. Thus, this study was carried out to investigate whether HJ has a beneficial effect on the progression of AD in an animal model. A methanolic extract of HJ (500 mg/kg/day) was intragastrically administered to 5-month-old APP/PS1 transgenic (Tg-APP/PS1) mice for 2.5 months. Novel object recognition and Y-maze alteration tests were used to assess cognitive function, and an immunohistochemical assay was performed to assess amyloid β (Aβ)deposition, tau phosphorylation and gliosis. An in vitro assay using a microglial cell line was also performed to investigate the anti.inflammatory effects of HJ. Our results revealed that HJ significantly decreased the mRNA and protein expression levels of tumor necrosis factor-α (TNF.α), interleukin (IL)-1β, IL-6 and inducible nitric oxide synthase (iNOS) induced by lipopolysaccharide in the microglial cell line. The administration of HJ for 2 months improved the cognitive function of Tg-APP/PS1 mice. HJ notably reduced the area occupied by Aβ and neurofibrillary tangles, and the number of activated astrocytes and microglia in the cortex of Tg-APP/PS1 mice. The findings of our study suggest that HJ has the therapeutic potential to inhibit the progression of AD and to improve cognitive deterioration in Tg-APP/PS1 mice.
Alzheimer's diseaseCognitionHumulus japonicusInflammationα-amyloid plaque
Spandidos Publ Ltd
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Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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