Octaminomycins A and B, cyclic octadepsipeptides active against Plasmodium falciparum = 항말라리아 Octaminomycins A와 B

Cited 10 time in scopus
Metadata Downloads
Title
Octaminomycins A and B, cyclic octadepsipeptides active against Plasmodium falciparum = 항말라리아 Octaminomycins A와 B
Author(s)
Jun-Pil Jang; T Nogawa; Y Futamura; T Shimizu; D Hashizume; S Yakahashi; Jae-Hyuk JangJong Seog Ahn; H Osada
Bibliographic Citation
Journal of Natural Products, vol. 80, no. 1, pp. 134-140
Publication Year
2017
Abstract
Two new cyclic octadepsipeptides, octaminomycins A (1) and B (2), were isolated from a microbial metabolite fraction library of Streptomyces sp. RK85-270 based on Natural Products Plot screening. Their structures were elucidated on the basis of HRESIMS, 1D and 2D NMR spectroscopic data, and MS/MS experiments for sequence analysis. The absolute configurations of the constituent amino acid residues were determined by a combination of single-crystal X-ray diffraction and Marfey's methodology. Notably, octaminomycins A (1) and B (2) showed good in vitro antiplasmodial activity against chloroquine-sensitive as well as chloroquine-resistant strains with no cytotoxicity up to 30 μM. (Chemical Equation Presented)
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/acs.jnatprod.6b00758
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.