Tilianin inhibits MUC5AC expression mediated via down-regulation of EGFR-MEK-ERK-SP1 signaling pathway in NCI-H292 human airway cells

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Title
Tilianin inhibits MUC5AC expression mediated via down-regulation of EGFR-MEK-ERK-SP1 signaling pathway in NCI-H292 human airway cells
Author(s)
W Y Song; Y S Song; Hyung Won RyuSei-Ryang Oh; J T Hong; D Y Yoon
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 27, no. 1, pp. 49-56
Publication Year
2017
Abstract
In the human airway, mucus exists to protect the respiratory system as a primary barrier of the innate immune system. However, hyperexpressed mucus limits airflow, resulting in a decrease of lung function. Among more than 20 mucin family members, MUC5AC and MUC5B are major glycoproteins in human airway mucus. The epidermal growth factor receptor (EGFR) signaling pathway is one of the mechanisms of these mucins expression and specificity protein-1 (Sp1) transcription factor is the downstream signal of this pathway, playing pivotal roles in mucin expression. Even though there are some drugs for treating mucus hypersecretion, no drug has proven effects on humans. We found that the flavonoid tilianin regulated MUC5AC expression and also inhibited Sp1 phosphorylation. In this study, we investigated how tilianin would modulate EGFR signaling and regulate mucin production. In conclusion, tilianin inhibited MUC5AC expression mediated via modulating the EGFR-MEK-ERK-Sp1 signaling pathway in NCI-H292 human airway epithelial cells. This study may provide the basis for the novel treatment of mucus hypersecretion.
Keyword
Chronic obstructive pulmonary diseaseEpidermal growth factorMucin 5ACSpecificity protein-1Tilianin
ISSN
1017-7825
Publisher
South Korea
DOI
http://dx.doi.org/10.4014/jmb.1610.10012
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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