Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans
Cited 7 time in 
Metadata Downloads
- Title
- Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans
- Author(s)
- Ji Young Park; Su Hwan Lim; Bo Ram Kim; Hyung Jae Jeong; Hyung Jun Kwon; G Y Song; Young Bae Ryu; Woo Song Lee
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry Letters, vol. 27, no. 14, pp. 3060-3064
- Publication Year
- 2017
- Abstract
- Sialidases are key virulence factors that remove sialic acid from host cell surface glycans, thus unmasking receptors to facilitate bacterial adherence and colonization. In this study, we report the isolation and characterization of novel inhibitors of the Streptococcus pneumoniae sialidases NanA, NanB, and NanC from Myristica fragrans seeds. Of the isolated compounds (1-12), malabaricone C showed the most pneumococcal sialidases inhibition (IC50 of 0.3μM for NanA, 3.6μM for NanB, and 2.9μM for NanC). These results suggested that malabaricone C and neolignans could be potential agents for combating S. pneumoniae infection agents
- ISSN
- 0960-894X
- Publisher
- Elsevier
- Type
- Article
- Appears in Collections:
- Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
- Files in This Item:
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.